Yoshiaki Ito Selected Research

Core Binding Factor Alpha 3 Subunit

11/2011	Neuroblastoma cell proliferation is sensitive to changes in levels of RUNX1 and RUNX3 protein.
10/2010	Lack of RUNX3 inactivation in columnar cell lesions of breast.
2/2009	RUNX3 inactivation in colorectal polyps arising through different pathways of colonic carcinogenesis.
1/2009	RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression.
3/2007	Targets of genome copy number reduction in primary breast cancers identified by integrative genomics.
9/2006	Down-regulation of RUNX1, RUNX3 and CBFbeta in hepatocellular carcinomas in an early stage of hepatocarcinogenesis.
7/2006	RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer.

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Yoshiaki Ito Research Topics

Disease

46	Neoplasms (Cancer) 01/2022 - 02/2003
22	Stomach Neoplasms (Stomach Cancer) 01/2022 - 11/2002
17	Thrombosis (Thrombus) 01/2022 - 02/2012
12	Chronic Limb-Threatening Ischemia 06/2022 - 02/2015
11	Myocardial Infarction 01/2022 - 11/2002
9	Hemorrhage 01/2021 - 11/2016
8	Ischemia 01/2022 - 04/2013
8	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 01/2005
7	Wounds and Injuries (Trauma) 06/2022 - 02/2015
7	Type 2 Diabetes Mellitus (MODY) 01/2020 - 01/2004
7	Carcinogenesis 06/2019 - 11/2006
6	Breast Neoplasms (Breast Cancer) 01/2022 - 07/2006
6	Leukemia 09/2008 - 02/2002
5	Metaplasia 01/2022 - 08/2004
5	Hepatocellular Carcinoma (Hepatoma) 11/2021 - 09/2006
5	Death (Near-Death Experience) 01/2021 - 02/2012
4	Adenoma (Adenomas) 10/2020 - 09/2008
4	Coronary Artery Disease (Coronary Atherosclerosis) 10/2020 - 03/2016
4	Malnutrition (Nutritional Deficiencies) 01/2019 - 12/2007
3	Genomic Instability 01/2022 - 01/2017
3	Infections 01/2022 - 03/2017
3	No-Reflow Phenomenon 12/2021 - 01/2017
3	Diabetes Mellitus 03/2021 - 03/2016
3	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 05/2010
3	Hypersensitivity (Allergy) 01/2020 - 07/2013
3	Osteoarthritis 01/2019 - 02/2010
3	Colonic Neoplasms (Colon Cancer) 05/2018 - 09/2008
3	Insulin Resistance 11/2017 - 01/2005
3	Neuroblastoma 08/2013 - 08/2007
3	Hyperplasia 10/2010 - 04/2002
2	Lung Neoplasms (Lung Cancer) 05/2022 - 01/2004
2	Fanconi Anemia (Fanconi's Anemia) 01/2022 - 01/2018
2	Ischemic Stroke 01/2021 - 12/2020
2	Atrial Fibrillation 01/2021 - 11/2016
2	Arthritis (Polyarthritis) 01/2021 - 06/2010
2	ST Elevation Myocardial Infarction 10/2020 - 01/2019
2	Neoplasm Metastasis (Metastasis) 06/2019 - 01/2010
2	AIDS-Related Complex (ARC) 10/2018 - 06/2018
2	Anemia 11/2017 - 11/2016
2	Atherosclerosis 03/2016 - 01/2005
2	Osteosarcoma (Osteogenic Sarcoma) 10/2013 - 07/2013
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2012 - 03/2004
2	Adenocarcinoma 05/2011 - 01/2010
2	Ductal Carcinoma 10/2010 - 01/2009
2	Noninfiltrating Intraductal Carcinoma (DCIS) 10/2010 - 01/2009
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/2010 - 05/2007
2	Body Weight (Weight, Body) 03/2009 - 02/2002
2	Weight Loss (Weight Reduction) 03/2009 - 12/2007
2	Obesity 11/2008 - 01/2005
2	Genetic Translocation (Chromosomal Translocation) 05/2007 - 01/2005

Drug/Important Bio-Agent (IBA)

25	Transcription Factors (Transcription Factor)IBA 01/2022 - 10/2002
20	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2002
8	omega-Chloroacetophenone (Mace)IBA 01/2019 - 08/2009
8	Messenger RNA (mRNA)IBA 11/2011 - 01/2004
7	Core Binding Factor Alpha 3 SubunitIBA 11/2011 - 07/2006
7	Transforming Growth Factor beta (TGF-beta)IBA 05/2010 - 04/2002
5	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2004
5	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 01/2021 - 11/2016
5	MicroRNAs (MicroRNA)IBA 01/2021 - 11/2017
4	Biomarkers (Surrogate Marker)IBA 12/2021 - 11/2007
4	Core Binding Factor alpha SubunitsIBA 01/2018 - 03/2013
4	Leucine (L-Leucine)FDA Link 09/2015 - 02/2002
3	Oncogene Proteins (Oncogene Protein)IBA 01/2022 - 01/2010
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2021 - 08/2018
3	Biological ProductsIBA 07/2013 - 07/2006
3	AdiponectinIBA 02/2009 - 01/2005
3	HDL CholesterolIBA 02/2009 - 01/2005
3	Caseins (Casein)FDA Link 12/2007 - 02/2002
2	Phenobarbital (Luminal)FDA Link 01/2022 - 07/2011
2	B7-H1 AntigenIBA 12/2021 - 10/2021
2	Pharmaceutical PreparationsIBA 12/2021 - 01/2017
2	CobaltIBA 10/2020 - 01/2019
2	Everolimus FDA Link 10/2020 - 01/2019
2	ChromiumIBA 10/2020 - 01/2019
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2020 - 01/2012
2	PapaverineIBA 05/2018 - 01/2016
2	AntioxidantsIBA 01/2018 - 07/2013
2	ChromatinIBA 01/2018 - 06/2008
2	Sirolimus (Rapamycin)FDA Link 04/2016 - 11/2015
2	Histones (Histone)IBA 01/2012 - 06/2008
2	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 05/2011 - 11/2002
2	Carcinoembryonic AntigenIBA 07/2010 - 07/2009
2	beta CateninIBA 05/2010 - 09/2008
2	TCF Transcription FactorsIBA 05/2010 - 09/2008
2	Histone Deacetylase InhibitorsIBA 02/2010 - 04/2007
2	Histone Deacetylases (Histone Deacetylase)IBA 02/2010 - 04/2007
2	Muscle Proteins (Muscle Protein)IBA 10/2009 - 12/2007
2	Monoclonal AntibodiesIBA 01/2009 - 09/2005
2	matrigelIBA 03/2007 - 07/2006
2	Insulin (Novolin)FDA Link 01/2005 - 02/2002

Therapy/Procedure

20	Stents 01/2022 - 02/2012
12	Therapeutics 01/2022 - 11/2007
10	Drug-Eluting Stents 10/2020 - 11/2015
8	Renal Dialysis (Hemodialysis) 01/2022 - 02/2015
6	Surgical Amputation (Amputations) 01/2022 - 12/2015
5	Percutaneous Coronary Intervention 01/2021 - 11/2002
3	Transcatheter Aortic Valve Replacement 09/2021 - 06/2018
3	Catheters 01/2020 - 04/2013
3	Limb Salvage 01/2019 - 12/2015
2	Immunotherapy 12/2021 - 10/2021